Precision Medicine Asia and National Cancer Center Hospital East Announce the Initiation of the LC-SCRUM-AP Genomic Screening Platform for the Asia-Pacific Region

December 21, 2022

TOKYO, Dec. 21, 2022 (GLOBE NEWSWIRE) -- Precision Medicine Asia Co., Ltd. (“PREMIA”) and National Cancer Center Hospital East (“NCCHE”) announced the initiation of the Lung Cancer Genomic Screening Project for Individualized Medicine in Asia Pacific (LC-SCRUM-AP), a genomic screening platform, which will be integrated with LC-SCRUM-Asia to create an international, large scale lung cancer clinicopathological genomic database for the region. Highlights LC-SCRUM-AP is a genomic screening platform for patients with advanced or recurrent non-small cell lung cancer.The aim is to further develop precision medicine in Asia by establishing a genomic screening infrastructure for the Asia-Pacific region.The integration of the LC-SCRUM-Asia and LC-SCRUM-AP databases will create an international, large-scale lung cancer clinicopathological database and contribute to the development of precision medicine in Asia. PREMIA, with the cooperation of NCCHE, initiated LC-SCRUM-AP by forming academic collaboration with sites in various countries in the Asia-Pacific region. By leveraging LC-SCRUM-Asia*1 led by NCCHE, PREMIA aims to establish genomic screening platform in the Asia-Pacific region and to develop precision medicines for patients with advanced or recurrent non-small cell lung cancer. BackgroundRecent advances in genomic analytic technologies, such as next generation sequencing (NGS), have led to the development of precision medicine, in which effective, personalized cancer treatments are developed based on the results of a genomic analysis of each individual cancer patient. In lung cancer, many drugs targeting alterations in EGFR, ALK, ROS1, BRAF, NTRK, MET, RET, and KRAS have been approved in Japan so far, only some of which are approved or available in countries in Asia-Pacific. Going forward, precision medicine in lung cancer is expected to accelerate, with the active development of therapies targeting other genomic alterations such as HER2 and EGFR exon 20 insertion. However, the frequency of each of these genomic alterations is rare, accounting for only 1-3% of non-small cell lung cancers excluding genomic mutations in EGFR. As a result, the establishment of a large-scale, international genomic screening platform with the cooperation of Japan and other countries through academic collaboration, is critical. With the launch of LC-SCRUM-AP, approximately 20 institutions in Thailand, Malaysia, Vietnam, Singapore, Indonesia, Australia and Taiwan, will participate through academic collaboration. In cooperation with NCCHE, PREMIA is mainly responsible for launching participating sites and for developing and establishing the genomic screening platform in the Asia-Pacific region. Clinical development based on LC-SCRUM-Asia/AP and establishment of an international clinico-genomic database for lung cancer The establishment of a screening infrastructure for lung cancer in the Asia-Pacific region will make it possible to conduct genomic screening on a larger scale and accelerate the development of new molecular targeting agents for various genomic alterations. In addition, by integrating the LC-SCRUM-Asia and LC-SCRUM-AP databases and creating a clinico-genomic database for the Asia-Pacific region, large-scale, real-world data will be accumulated, which is expected to contribute meaningfully to the development of precision medicine in the Asia-Pacific region. With the cooperation of PREMIA and organizations in other countries in the region, LC-SCRUM-AP will work to further promote development of precision medicine in Asia-Pacific. LC-SCRUM-AsiaLC-SCRUM-Japan, a genomic screening platform launched by the National Cancer Center in 2013, in collaboration with medical institutions and pharmaceutical companies (Representative: Koichi Goto, Chief of Department of Thoracic Oncology, NCCHE), expanded to include East Asia in 2019. Since then, it has been operating as “LC-SCRUM-Asia", an international genomic screening project in which more than 17,000 lung cancer patients have participated as of September 2022, and during which time, large-scale genomic analysis has been conducted with the goal of developing new therapeutic and diagnostic agents for lung cancer. Going forward, academia and industry will continue to work together to promote the development of novel therapeutics and diagnostics for the optimal medical treatment of lung cancer. More information about LC-SCRUM-Asia can be found at: About Precision Medicine Asia (PREMIA)PREMIA offers an integrated platform for the development of innovative oncology therapies and diagnostics in Asia, the fastest growing market for the pharmaceutical industry. PREMIA also manages Japan’s nationwide clinical-genomic lung cancer registry, LC-SCRUM-Asia, the only such database in Asia. The registry currently includes more than 17,000 patients and allows an efficient patient identification process for clinical trial enrollment through participation by more than 200 hospitals in Japan and Taiwan, with the addition of hospitals in Southeast Asia through LC-SCRUM-AP from 2022 onwards. For more information, please visit About National Cancer Center Hospital East (NCCHE)The National Cancer Center Hospital East (NCCHE) was established in 1992. It is a leading specialized cancer hospital in Japan, treating over 9,000 new patients each year. NCCHE is designated by the national government as a core hospital for clinical research and a core hospital for cancer genomic treatment, among others. Together with its adjoining facility, the Exploratory Oncology Research & Clinical Trial Center (NCC-EPOC), NCC Hospital East has produced many achievements as a research and development center with its strong international network. NCCHE has been promoting the development of innovative cancer medicines and medical devices and cutting-edge personalized treatment, including genomic medicine. Contact information for inquiries:Precision Medicine AsiaVivian LiuDirector, Corporate OperationsTel: A photo accompanying this announcement is available at

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